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Reactivity | Human Mouse Rat |
Tested applications | WB IF IP |
Recommended Dilution | WB 1:200 - 1:2000 IF 1:50 - 1:200 IP 1:20 - 1:50 |
Calculated MW | 275kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human ACACA |
Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | ACC; ACAC; ACC1; ACCA; ACACAD; |
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
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