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Reactivity | Human |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:1000 IHC 1:50 - 1:100 |
Calculated MW | 15kDa |
Observed MW | Refer to Figures |
Immunogen | A synthetic peptide of human H2AFX |
Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | H2A.X; H2A/X; H2AX |
Histone H2A.X belongs to the histone H2A family, which is synthesized in G1 and S phase. It is involved in nucleosomal organization of chromatin together with other histone proteins, and is specially important for recombination between immunoglobulin switch regions. H2A.X becomes phosphorylated on serine 139 (to form gamma-H2AFX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, which promotes DNA repair and maintains genomic stability.
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