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- SPECIFICATION
- BACKGROUND
- DOCUMENTS
- REVIEW
ADDITIONAL INFORMATION
SYNONYMS
HNF3B; TCF3B; HNF-3-beta; HNF3β/FOXA2
REACTIVITY
Human,Rat
TESTED APPLICATIONS
ELISA,WB,IF/ICC,IP
RECOMMENDED DILUTION
WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200|IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
CALCULATED MW
48kDa
OBSERVED MW
52kDa
IMMUNOGEN
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HNF3β/FOXA2 (Q9Y261).
POSITIVE SAMPLES
HepG2,Rat lung
CELLULAR LOCALIZATION
Cytoplasm,Nucleus,
STORAGE BUFFER
Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
BACKGROUND
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
REVIEW
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