CDC25C-Monoclonal Antibodies

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CDC25C

Qty


Total
$220
Catalog #
A0444
Antibody Type
Monoclonal Antibody
Gene ID
995
Swiss Prot
P30307
Size
Species
Mouse
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:1000
Calculated MW53kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human CDC25C
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationq
Synonymcdc25C; CDC25C;CDC25
Images
  • A0444: image 1

    Western blot analysis of extracts of various cell lines, using CDC25C antibody.

Background

cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis (1). cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint (2). When phosphorylated at Ser216, cdc25C binds to members of the 14-3-3 family of proteins, sequestering cdc25C in the cytoplasm preventing premature mitosis (3). The checkpoint kinases Chk1 and Chk2 phosphorylate cdc25C at Ser216 in response to DNA damage (4,5).

Protocol

N/A

MSDS
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