CDKN1A-Methylated Antibodies

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CDKN1A

Qty


Total
$220
Catalog #
A11454
Antibody Type
Polyclonal Antibody
Gene ID
1026
Swiss Prot
P38936
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityMouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW21kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human CDKN1A
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymCAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1
Images
  • A11454: image 1

    Immunofluorescence analysis of MCF7 cells using CDKN1A antibody.

Background

The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S (1). However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D (2). The carboxy-terminal region of p21 is sufficient to bind and inhibit PCNA, a subunit of DNA polymerase, and may coordinate DNA replication with cell cycle progression (3). Upon UV damage or during cell cycle stages when cdc2/cyclin B or CDK2/cyclin A is active, p53 is phosphorylated and upregulates p21 transcription via a p53-responsive element (4). Protein levels of p21 are downregulated through ubiquitination and proteasomal degradation (5).

Protocol

N/A

MSDS
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