CDKN1B-Monoclonal Antibodies

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CDKN1B

Qty


Total
$220
Catalog #
A0290
Antibody Type
Polyclonal Antibody
Gene ID
1027
Swiss Prot
P46527
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:200 - 1:500 IHC 1:50 - 1:200 IF 1:20 - 1:50
Calculated MW27kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human CDKN1B
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationq
SynonymCDKN1B;CDKN4;KIP1;MEN1B;MEN4;P27KIP1
Images
  • A0290: image 1

    Western blot analysis of extracts of various cell lines, using CDKN1B antibody.

  • A0290: image 2

    Immunohistochemistry of paraffin-embedded rat brain using CDKN1B antibody at dilution of 1:200 (400x lens).

  • A0290: image 3

    Immunohistochemistry of paraffin-embedded rat brain using CDKN1B antibody at dilution of 1:200 (400x lens).

  • A0290: image 4

    Immunohistochemistry of paraffin-embedded mouse kidney using CDKN1B antibody at dilution of 1:200 (400x lens).

Background

CDKN1B Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of CDKN1B are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of CDKN1B can be induced by treatment with interleukin 2 or other mitogens; this involves phosphorylation of CDKN1B and its degradation by the ubiquitin-proteasome pathway (1-4).

Protocol

N/A

MSDS
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