CTBP1-Monoclonal Antibodies

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CTBP1

Qty


Total
$220
Catalog #
A1707
Antibody Type
Polyclonal Antibody
Gene ID
1487
Swiss Prot
Q13363
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF IP CHIP
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 ChIP 1:20 - 1:100
Calculated MW48kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human CTBP1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationft
SynonymBARS; MGC104684;
Images
  • A1707: image 1

    Western blot analysis of extracts of various cell lines, using CTBP1 antibody.

  • A1707: image 2

    Immunohistochemistry of paraffin-embedded human liver cancer using CTBP1 antibody at dilution of 1:100 (400x lens).

  • A1707: image 3

    Immunofluorescence analysis of U2OS cell using CTBP1 antibody. Blue: DAPI for nuclear staining.

Background

CtBP1 (C-terminal binding protein 1) was first recognized as a cellular factor that interacts with the C-terminal portion of adenovirus E1A, a protein involved in the transcriptional regulation of key cellular genes (1). CtBP1 is able to regulate gene activity through its intrinsic dehydrogenase activity (2,3) and by interacting with Polycomb Group (PcG) proteins during development (4). Along with its homologue, CtBP2, it acts as a transcriptional corepressor of zinc-finger homeodomain factor deltaEF1 to regulate a wide range of cellular processes through transrepression mechanisms (5). Through its direct interaction with PRDM16, CtBP1 has been shown to be involved in brown adipose tissue differentiation by mediating the repression of white fat genes and directing differentiation toward the brown fat gene program (6). CtBP1 also plays a role in lipid metabolic pathways and membrane fission by regulating the fission machinery operating Golgi tubular networks (7). CtBP1 has recently been shown to repress transcription of BRCA1 via a redox regulated mechanism (8). Furthermore, it is thought that downregulation of BRCA1 and E-cadherin in invasive ductal breast carcinoma correlates directly with activation of CtBP1 (9).

Protocol

N/A

MSDS
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