DFFA-Monoclonal Antibodies

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DFFA

Qty


Total
$220
Catalog #
A0507
Antibody Type
Polyclonal Antibody
Gene ID
1676
Swiss Prot
O00273
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW37kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human DFFA
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationb
SynonymDFF1; ICAD; DFF-45;
Images
  • A0507: image 1

    Western blot analysis of extracts of HeLa cell line, using DFFA antibody.

Background

Apoptosis is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF), heterodimer of 40-kDa (DFFB) and 45-kDa (DFFA) subunits, is one of the major endonucleases responsible for internucleosomal DNA cleavage during apoptosis. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF activated after cleavage of DFFA by caspase-3 followed by its dissociation from DFFB. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. DFFA appears to be a 45-kDa protein despite the predicated MW of 37 kDa.

Protocol

N/A

MSDS
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