FGFR2-Polyclonal Antibodies

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FGFR2

Qty


Total
$220
Catalog #
A0044
Antibody Type
Polyclonal Antibody
Gene ID
2263
Swiss Prot
P21802
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat Monkey
Tested applicationsWB IHC IF FC
Recommended DilutionWB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 FC 1:20 - 1:50
Calculated MW79kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human FGFR2
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymFGFR2;BEK;BFR-1;CD332;CEK3;CFD1;ECT1;FLJ98662;JWS;K-SAM; KGFR;TK14;TK25
Background

Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3, and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCγ (4,5).

Protocol

N/A

MSDS
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