GFAP-Monoclonal Antibodies

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GFAP

Qty


Total
$220
Catalog #
A11563
Antibody Type
Polyclonal Antibody
Gene ID
2670
Swiss Prot
P14136
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityMouse
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW50kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human GFAP
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymGFAP;FLJ45472 ;
Images
  • A11563: image 1

    Western blot analysis of extracts of various cell lines, using GFAP antibody.

Background

The cytoskeleton consists of three types of cytosolic fibers: microfilaments (actin filaments), intermediate filaments, and microtubules. Major types of intermediate filaments are specifically expressed in particular cell types: cytokeratins in epithelial cells, glial fibrillary acidic protein (GFAP) in glial cells, desmin in skeletal, visceral, and certain vascular smooth muscle cells, vimentin in cells of mesenchymal origin, and neurofilaments in neurons. GFAP and vimentin form intermediate filaments in astroglial cells and modulate their motility and shape (1). In particular, vimentin filaments are present at early developmental stages, while GFAP filaments are characteristic of differentiated and mature brain astrocytes. Thus, GFAP is commonly used as a marker for intracranial and intraspinal tumors arising from astrocytes (2). In addition, GFAP intermediate filaments are also present in non-myelin-forming Schwann cells in the peripheral nervous system (3).

Protocol

N/A

MSDS
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