HDAC1-Monoclonal Antibodies

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HDAC1

Qty


Total
$220
Catalog #
A0421
Antibody Type
Monoclonal Antibody
Gene ID
3065
Swiss Prot
Q13547
Size
Species
Mouse
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB
Recommended DilutionWB 1:200 - 1:2000
Calculated MW55kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human HDAC1
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbfiptt
SynonymHDAC1;DKFZp686H12203;GON-10;HD1;RPD3;RPD3L1; Histone Deacetylase 1;
Images
  • A0421: image 1

    Western blot analysis of extracts of HepG2 cell line, using HDAC1 antibody.

Background

Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription (1,2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes (3). In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases (5). Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents (6,7).

Protocol

N/A

MSDS
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