Accelerate Your Biomolecule
and Bioassay Research
and Bioassay Research
sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-617.299.7367 (Int’l)
For quotations, please use our online quotation form, and you may also contact us by
sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC IF |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Calculated MW | 39kDa |
| Observed MW | Refer to figures |
| Immunogen | Recombinant protein of human HNRNPA1 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | j |
| Synonym | ALS19; ALS20; HNRPA1; IBMPFD3; HNRPA1L3; hnRNP A1; hnRNP-A1; |
Western blot analysis of extracts of various cell lines, using HNRNPA1 antibody.
Immunohistochemistry of paraffin-embedded Human gastric injury using HNRNPA1 antibody at dilution of 1:100 (x40 lens)..
Immunohistochemistry of paraffin-embedded Human mammary cancer using HNRNPA1 antibody at dilution of 1:100 (x40 lens)..
Immunohistochemistry of paraffin-embedded liver cancer using HNRNPA1 antibody at dilution of 1:100 (x40 lens)..
Immunohistochemistry of paraffin-embedded Mouse kidney using HNRNPA1 antibody at dilution of 1:100 (x40 lens)..
Immunohistochemistry of paraffin-embedded Rat brain using HNRNPA1 antibody at dilution of 1:100 (x40 lens)..
Immunohistochemistry of paraffin-embedded human colon using HNRNPA1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human lung cancer using HNRNPA1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human gastric using HNRNPA1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat liver using HNRNPA1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded mouse stomach using HNRNPA1 antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis of A549 cell using HNRNPA1 antibody.
Immunofluorescence analysis of A549 cell using HNRNPA1 antibody.
Immunofluorescence analysis of A549 cell using HNRNPA1 antibody.
Immunofluorescence analysis of A549 cell using HNRNPA1 antibody.
Immunofluorescence analysis of A549 cell using HNRNPA1 antibody.
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.
N/A
Copyrights © 2014 NEO Group 245 First Street, 18th Floor, Cambridge MA 02142 888.733.6849
