HNRNPC-Polyclonal Antibodies

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HNRNPC

Qty


Total
$220
Catalog #
A0057
Antibody Type
Polyclonal Antibody
Gene ID
3183
Swiss Prot
P07910
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW41kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human HNRNPC
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationj
SynonymC1;C2;HNRNP;HNRPC;SNRPC;Heterogeneous nuclear ribonucleoproteins C1/C2 antibody;
Images
  • A0057: image 1

    Western blot analysis of extracts of various cell lines, using HNRNPC antibody.

Background

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are predominantly nuclear RNA-binding proteins that form complexes with RNA polymerase II transcripts. These proteins function in a variety of cellular activities, ranging from transcription and pre-mRNA processing in the nucleus to cytoplasmic mRNA translation and turnover. hnRNP C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and proliferation. A novel nuclear export is activated by the ROCK signaling pathway to exclude hnRNP C1/C2 from the nucleus, by which the compartmentalization of specific hnRNP components is disturbed in apoptotic cells. Overexpression of hnRNP C1/C2 in hepatocellular carcinoma (HCC) tissues has been reported in 70 HCC samples, suggesting its potential as a protein tumor marker.

Protocol

N/A

MSDS
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