ID2-Monoclonal Antibodies

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ID2

Qty


Total
$220
Catalog #
A0996
Antibody Type
Polyclonal Antibody
Gene ID
3398
Swiss Prot
Q02363
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW18kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human ID2
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationk
SynonymID2;GIG8;ID2A;ID2H;MGC26389;bHLHb26 ;
Images
  • A0996: image 1

    Western blot analysis of 293T cell lysate using ID2 antibody.

Background

Inhibitor of DNA-binding-2 (Id2) is a member of the Id proteins which belong to the helix-loop-helix (HLH) protein family. The Id protein functions by binding to specific transcription factors and preventing their dimerization and DNA binding (1-3). Id2 interacts with a wide variety of transcription factors including E proteins (5), TCS (4), Pax (6) and the tumor suppressor Rb (1). Id2 has been shown to be important in regulating cellular differentiation, proliferation, development and tumorgenesis (7-9). In tumor cells, increased levels of Id2 functionally inactivate Rb, leading to cellular transformation and cancer (10,11). Id2 is therefore a promising therapeutic target for treatment of cancer (12).

Protocol

N/A

MSDS
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