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+1-888.733.6849
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| Reactivity | Human Mouse Rat |
| Tested applications | WB ICC |
| Recommended Dilution | WB 1:500 - 1:2000 ICC 1:50 - 1:200 |
| Calculated MW | 130kDa |
| Observed MW | Refer to Figures |
| Immunogen | A synthetic peptide of human Jak2 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | bo |
| Synonym | JAK2;JTK10;Tyrosine-protein kinase JAK2;Janus kinase 2; |
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains.
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