LCN2-Monoclonal Antibodies

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LCN2

Qty


Total
$220
Catalog #
A2092
Antibody Type
Polyclonal Antibody
Gene ID
3934
Swiss Prot
P80188
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Calculated MW23kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human LCN2
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymLCN2; 24p3; MSFI; NGAL; Lipocalin-2;
Images
  • A2092: image 1

    Western blot analysis of extracts of SW480 cell lines, using LCN2 antibody.

  • A2092: image 2

    Immunofluorescence analysis of A549 cell using LCN2 antibody. Blue: DAPI for nuclear staining.

Background

Lipocalin-2, a member of the lipocalin family of proteins, was originally identified as a gelatinase-associated component of neutrophil secretory granules (1). Lipocalin-2 is involved in innate immunity, iron homeostasis, and apoptosis. Lipocalin-2 limits bacterial growth by binding to bacterial siderophores and sequestering iron (2-4). In mammalian cells, iron-loaded lipocalin-2 binds to its receptor, 24p3R, and is internalized, thereby releasing iron and increasing the intracellular iron concentration (5). Conversely, iron-free lipocalin-2 promotes apoptosis (5). Lipocalin-2 is also expressed in adipose tissue and promotes insulin resistance in cultured mouse adipocytes (6).

Protocol

N/A

MSDS
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