LMNB1-Monoclonal Antibodies

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LMNB1

Qty


Total
$220
Catalog #
A1910
Antibody Type
Polyclonal Antibody
Gene ID
4001
Swiss Prot
P20700
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW66kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human LMNB1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymLMN; ADLD; LMN2; LMNB;
Images
  • A1910: image 1

    Western blot analysis of extracts of various cell lines, using LMNB1 antibody.

  • A1910: image 2

    Immunofluorescence analysis of U2OS cells using LMNB1 antibody.

Background

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

Protocol

N/A

MSDS
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