MYC-Methylated Antibodies

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MYC

Qty


Total
$220
Catalog #
A11394
Antibody Type
Polyclonal Antibody
Gene ID
4609
Swiss Prot
P01106
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityMouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:100
Calculated MW57kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human MYC
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonymc-Myc; MRTL;bHLHe39 ;c-Myc;Myc proto-oncogene protein ;Proto-oncogene c-Myc ;Transcription factor p64 ;
Images
  • A11394: image 1

    Immunohistochemistry of paraffin-embedded mouse liver using MYC antibody at dilution of 1:100 (40x lens).

  • A11394: image 2

    Immunohistochemistry of paraffin-embedded rat heart using MYC antibody at dilution of 1:100 (40x lens).

Background

Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior including proliferation, differentiation and apoptosis (1). These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription (2). Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families (1). The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior (1). The Mad family consists of four related proteins; Mad1, Mad2 (Mxi1), Mad3 and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes such as proliferation, transformation and prevention of apoptosis by inhibiting transcription (3,4).

Protocol

N/A

MSDS
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