NEDD4L-Monoclonal Antibodies

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NEDD4L

Qty


Total
$220
Catalog #
A8085
Antibody Type
Polyclonal Antibody
Gene ID
23327
Swiss Prot
Q96PU5
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW112kDa
Observed MWRefer to figures
ImmunogenRecombinant protein of human NEDD4L
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymRSP5; NEDD4-2; NEDD4.2; hNEDD4-2;
Images
  • A8085: image 1

    Western blot analysis of extracts of various cell lines, using NEDD4L antibody.

  • A8085: image 2

    Immunohistochemistry of paraffin-embedded rat kidney using NEDD4L antibody at dilution of 1:200 (40x lens).

  • A8085: image 3

    Immunohistochemistry of paraffin-embedded human prostate using NEDD4L antibody at dilution of 1:200 (40x lens).

Background

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Protocol

N/A

MSDS
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