Phospho-ABL1-Y204 -Monoclonal Antibodies

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Phospho-ABL1-Y204

Qty


Total
$300
Catalog #
AP0003
Antibody Type
Polyclonal Antibody
Gene ID
25
Swiss Prot
P00519
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IF
Recommended DilutionWB 1:500 - 1:2000 IF 1:50 - 1:200
Observed MWRefer to Figures
ImmunogenA phospho specific peptide corresponding to residues surrounding Y204 of human ABL1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbr
SynonymABL; JTK7; p150; c-ABL; v-abl; bcr/abl
Images
  • AP0003: image 1

    Immunofluorescence analysis of MCF7 cell using Phospho-ABL1-Y204 antibody. Blue: DAPI for nuclear staining.

  • AP0003: image 2

    Immunofluorescence analysis of GFP-RNF168 trangenic U2OS cell using Phospho-ABL1-Y204 antibody. Green:GFP-RNF168 fusion protein expression for DNA damage marker.Blue: DAPI for nuclear staining.RNF168(GFP) can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.

  • AP0003: image 3

    Immunofluorescence analysis of GFP-RNF168 trangenic U2OS cell using Phospho-ABL1-Y204 antibody. Green:GFP-RNF168 fusion protein expression for DNA damage marker.Blue: DAPI for nuclear staining.RNF168(GFP) can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.

Background

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Protocol

N/A

MSDS
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