Phospho-APP-T668-Monoclonal Antibodies

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Phospho-APP-T668

Qty


Total
$300
Catalog #
AP0006
Antibody Type
Polyclonal Antibody
Gene ID
351
Swiss Prot
P05067
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW87kDa
Observed MWRefer to Figures
ImmunogenA phospho specific peptide corresponding to residues surrounding T668 of human APP
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbio
SynonymAAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;
Images
  • AP0006: image 1

    Western blot analysis of extracts of C6 cell line, using Phospho-APP-T668 antibody.

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Protocol

N/A

MSDS
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