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sales@neoscientific.com
+1-888.733.6849
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| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC IF IP RIP |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:20 - 1:50 RIP 1:20 - 1:50 |
| Calculated MW | 25kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human RAN |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | dj |
| Synonym | RAN;ARA24;Gsp1;TC4 ; |
Ran is a small GTPase of the Ras family that plays a central role in the spacial and temperal organization of eukaryotic cells. During interphase, Ran-GDP localizes to the cytoplasm and Ran-GTP to the nucleus. This polarized localization of Ran ensures its role in nuclear transport (1). During mitosis, Ran-GTP is chromatin associated, where it promotes spindle assembly and nuclear envolope formation (1,2). In S phase, Ran-GTP associates with and inhibits MCM helicase, ensuring precise chromosomal DNA duplication during the cell cycle (3)
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