RRM1-Monoclonal Antibodies

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RRM1

Qty


Total
$220
Catalog #
A1152
Antibody Type
Polyclonal Antibody
Gene ID
6240
Swiss Prot
P23921
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW90kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human RRM1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentratione
SynonymRRM1;R1;RIR1;RR1 ;
Images
  • A1152: image 1

    Western blot analysis of extracts of various cell lines, using RRM1 antibody.

  • A1152: image 2

    Immunohistochemistry of paraffin-embedded human prostate using RRM1 antibody at dilution of 1:200 (40x lens).

  • A1152: image 3

    Immunohistochemistry of paraffin-embedded human gastric using RRM1 antibody at dilution of 1:200 (40x lens).

  • A1152: image 4

    Immunofluorescence analysis of HeLa cell using RRM1 antibody. Blue: DAPI for nuclear staining.

  • A1152: image 5

    Immunofluorescence analysis of MCF-7 cell using RRM1 antibody. Blue: DAPI for nuclear staining.

  • A1152: image 6

    Immunofluorescence analysis of A549 cell using RRM1 antibody. Blue: DAPI for nuclear staining.

Background

Ribonucleotide reductase catalyzes the rate-limiting step in the synthesis of deoxynucleotide triphosphates (dNTPs). The regulatory M1 subunit (RRM1) is present throughout the cell division cycle, but downregulated in quiescent cells (1). Research studies have demonstrated that RRM1 is involved in carcinogenesis and tumor progression, and its expression is correlated with resistance to chemotherapy in non-small cell lung cancer (2-4).

Protocol

N/A

MSDS
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