|Reactivity||Human Mouse Rat|
|Tested applications||WB IHC IF|
|Recommended Dilution||WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200|
|Observed MW||Refer to Figures|
|Immunogen||Recombinant protein of human RRM1|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
Western blot analysis of extracts of various cell lines, using RRM1 antibody.
Immunohistochemistry of paraffin-embedded human prostate using RRM1 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human gastric using RRM1 antibody at dilution of 1:200 (40x lens).
Immunofluorescence analysis of HeLa cell using RRM1 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of MCF-7 cell using RRM1 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of A549 cell using RRM1 antibody. Blue: DAPI for nuclear staining.
Ribonucleotide reductase catalyzes the rate-limiting step in the synthesis of deoxynucleotide triphosphates (dNTPs). The regulatory M1 subunit (RRM1) is present throughout the cell division cycle, but downregulated in quiescent cells (1). Research studies have demonstrated that RRM1 is involved in carcinogenesis and tumor progression, and its expression is correlated with resistance to chemotherapy in non-small cell lung cancer (2-4).
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