SAV1-Monoclonal Antibodies

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SAV1

Qty


Total
$220
Catalog #
A9980
Antibody Type
Polyclonal Antibody
Gene ID
60485
Swiss Prot
Q9H4B6
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB
Recommended DilutionWB 1:1000 - 1:4000
Calculated MW45kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human SAV1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymSAV; WW45; WWP4
Images
  • A9980: image 1

    Western blot analysis of extracts of various cells, using SAV1 antibody.

Background

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

Protocol

N/A

MSDS
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