TAPBP-Monoclonal Antibodies

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TAPBP

Qty


Total
$220
Catalog #
A1968
Antibody Type
Polyclonal Antibody
Gene ID
6892
Swiss Prot
O15533
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Calculated MW47kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human TAPBP
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymTPN; TAPA; TPSN; NGS17;
Images
  • A1968: image 1

    Western blot analysis of extracts of various cell lines, using TAPBP antibody.

  • A1968: image 2

    Immunohistochemistry of paraffin-embedded human stomach using TAPBP antibody at dilution of 1:200 (x400 lens).

  • A1968: image 3

    Immunofluorescence analysis of HeLa cell using TAPBP antibody. Blue: DAPI for nuclear staining.

Background

This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.

Protocol

N/A

MSDS
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