TOR1A-Monoclonal Antibodies

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TOR1A

Qty


Total
$220
Catalog #
A0170
Antibody Type
Monoclonal Antibody
Gene ID
1861
Swiss Prot
O14656
Size
Species
Mouse
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW35kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human TOR1A
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymDQ2;DYT1;Torsin-1A;Dystonia 1 protein antibody;Torsin family 1 member A antibody;
Images
  • A0170: image 1

    Western blot analysis of extracts of SH-SY5Y cell line, using TOR1A antibody.

Background

TorsinA is an AAA(+) protein that has been demonstrated as an endoplasmic reticulum (ER) chaperone protein involved in a sensitive reporter system for quantitation of processing through the secretory pathway. It is predominantly located in the lumen of the ER and nuclear envelope. TorsinA is responsible for early onset torsion dystonia (DYT1 dystonia), a dominantly inherited movement disorder and disease of basal ganglia function. DYT1 dystonia is commonly caused by the deletion of a glutamic acid (DeltaE) in the carboxyl terminal region of TorsinA, where the protein then aggregates in perinuclear inclusions instead of the ER. TorsinA is degraded primarily through the macroautophagy–lysosome pathway, whereas the TorsinA DeltaE mutant protein is degraded by both the proteasome and macroautophagy–lysosome pathways .

Protocol

N/A

MSDS
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