TSC1-Monoclonal Antibodies

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TSC1

Qty


Total
$220
Catalog #
A0721
Antibody Type
Monoclonal Antibody
Gene ID
7248
Swiss Prot
Q92574
Size
Species
Mouse
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:1000
Calculated MW130kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human TSC1
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationb
SynonymKIAA0243; LAM; MGC86987; TSC
Images
  • A0721: image 1

    Western blot analysis of extracts of various cell lines, using TSC1 antibody.

Background

TSC1, also named as KIAA0243 and TSC, is implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. In complex with TSC2, TSC1 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It seems not to be required for TSC2 GAP activity towards RHEB. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). The antibody is specific to TSC1.

Protocol

N/A

MSDS
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