TUBB1-Monoclonal Antibodies

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TUBB1

Qty


Total
$220
Catalog #
AC015
Antibody Type
Polyclonal Antibody
Gene ID
203068
Swiss Prot
P07437
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW50kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human TUBB
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymM40; OK/SW-cl.56; TUBB1; TUBB5;
Images
  • AC015: image 1

    Western blot analysis of extracts of HeLa cell line, using TUBB antibody.

Background

Microtubules are essential parts in eukaryotic cell structures, transportation, and mitosis and consists mainly of 2 soluble protein subunits, alpha and beta tubulin. Beta-tubulin binds to alpha tubulin to form tubulin heterodimer which is post-translationally modified. The tubulin dimer complex binds to GTP and assembles onto the positive ends of microtubules. After incorporation into the microtubules, bound GTP is hydrolyzed by beta tubulin. The stability of the dimer in the microtubules is depended on presence of beta tubulin, where dimer with GTP bound beta-tubulin is stable to microtubule incorporation. Mutation on beta-tubulin has been linked to anti-cancer drug resistance in lung cancers.

Protocol

N/A

MSDS
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