TYMS-Polyclonal Antibodies

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TYMS

Qty


Total
$220
Catalog #
A0017
Antibody Type
Polyclonal Antibody
Gene ID
7298
Swiss Prot
P04818
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IHC IF FC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:50 FC 1:20 - 1:50
Calculated MW36kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human TYMS
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymTS; TMS; HST422;
Images
  • A0017: image 1

    Western blot analysis of extracts of HeLa cell line, using TYMS antibody.

Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]

Protocol

N/A

MSDS
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