Tp53-Monoclonal Antibodies

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Tp53

Qty


Total
$220
Catalog #
A11481
Antibody Type
Polyclonal Antibody
Gene ID
7157
Swiss Prot
P02340
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IF
Recommended DilutionWB 1:500 - 1:2000 IF 1:50 - 1:100
Calculated MW44kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human Tp53
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonymbbl; bfy; bhy; p44; p53; Tp53
Images
  • A11481: image 1

    Immunofluorescence analysis using Tp53 antibody.

Background

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined.

Protocol

N/A

MSDS
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