Acrp30 Human, Trimeric-Adiponectin

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Acrp30 Human, Trimeric

Qty


Total
$65
Catalog #
CYPS-240
Size
Description
Trimeric form of Adiponectin Human trimeric form was expressed in HEK293 cells. The cysteine 39 was replaced with Alanine (C39A) 9. hAd-C39A can only form a trimer, but not a hexamer or an HMW form.
Additional Information
IntroductionAdiponectin is a hormone exclusively expressed from adipose tissue.Many studies demonstrate that Adiponectin has direct anti-diabetic, anti-atherogenic and anti-inflammatory functions. APM-1 can increase insulin sensitivity of skeletal muscle. Attenuate hepatic lipogenesis and gluconeogenesis, regulate NO production in endothelial cells, inhibit proliferation of smooth muscle cells and prevent lipid accumulation of macrophage cells.In the circulation, Adiponectin is present as three different oligomeric complexes, including the high molecular weight (HMW), the middle molecular weight (MMW, also called hexamer) and low molecular weigh (MMW, also called trimer) forms 8. Different oligomeric complex of Adiponectin activates different signaling pathways and exerts distinct functions.
SynonymsAcrp30, AdipoQ, GBP-28, APM-1, ACDC.
SourceHEK293 (Human embryonic kidney cell line).
Physical AppearanceFiltered White lyophilized (freeze-dried) powder.
FormulationFiltered (0.4
SolubilityAdd deionized water to a working volume of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
StabilityStore lyophilized Adiponectin at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Amino Acid SequenceETTTQGPGVL
LPLPKGAATG
WMAGIPGHPG
HNGAPGRDGR
DGTPGEKGEK
GDPGLIGPKG
DIGETGVPGA
EGPRGFPGIQ
GRKGEPGEGA
YVYRSAFSVG
LETYVTIPNM
PIRFTKIFYN
QQNHYDGSTG
KFHCNIPGLY
YFAYHIVYMK
DVKVSLFKKD
KAMLFTYDQY
QENNVDQASG
SVLLHLEVGD
QVWLQVYGEG
ERNGLYADND
NDSTFTGFLL
YHDTNDYKDD
DD
PurityGreater than 95% as determined by SDS-PAGE.
Biological ActivityED50= 3-8.5 μg/ml, as determined by its ability to inhibit proliferation of HASMCs induced by HB EGF.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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