Adiponectin is an important negative regulator in hematopoiesis and immune systems. It may be involved in ending inflammatory responses throµgh its inhibitory functions. Inhibits endothelial nf-kappa-b signaling throµgh a camp-dependent pathway. Inhibits tnf-alpha- induced expression of endothelial adhesion molecules. Involved in the control of fat metabolism and insulin sensitivity.
Acrp30, AdipoQ, GBP-28, APM-1, ACDC.
HEK293 (Human embryonic kidney cell line).
Sterile filtered and lyophilized from 0.5 mg/ml in PBS buffer.
Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely.
Store lyophilized APM-1 at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity of adiponectin mouse recombinant is >98% (HPLC and SDS PAGE analyzed).
Full-length mouse adiponectin activates AMP-activated protein kinase in hepatocyte and activates AMPK in HepG2 human hepatocytes at a concentration of 1000ng/ml corresponding to a Specific Activity of 1000IU/mg. Mouse adiponectin mammalian cell derived inhibits glucose production as shown by in-vitro gluconeogenesis assay in primary rat hepatocytes.
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