ALDOA Human-Aldolase

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ALDOA Human

Qty


Total
$65
Catalog #
ENPS-493
Size
Description
ALDOA Human Recombinant fused to 20 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 384 amino acids (1-364 a.a.)and having a molecular mass of 41.5 kDa. The ALDOA is purified by proprietary chromatographic techniques.
Additional Information
IntroductionAKR7A2 participates in the detoxification of aldehydes and ketones.AKR7A2 catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. AKR7A2 is involved in producing the neuromodulator gamma-hydroxybutyrate (GHB). AKR7A2 has extensive substrate specificity. AKR7A2 shows NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2 reduces 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). AKR7A2 reduces the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. AKR7A2 takes part in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
SynonymsFructose-bisphosphate aldolase A, Muscle-type aldolase, Lung cancer antigen NY-LU-1, ALDOA, ALDA, EC 4.1.2.13, GSD12, MGC10942, MGC17716, MGC17767, Aldolase-A.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered clear colorless solution.
FormulationThe ALDOA solution contains 20mM Tris-HCl pH-8, 0.1M NaCl and 20% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MPYQYPALTP
EQKKELSDIA
HRIVAPGKGI
LAADESTGSI
AKRLQSIGTE
NTEENRRFYR
QLLLTADDRV
NPCIGGVILF
HETLYQKADD
GRPFPQVIKS
KGGVVGIKVD
KGVVPLAGTN
GETTTQGLDG
LSERCAQYKK
DGADFAKWRC
VLKIGEHTPS
ALAIMENANV
LARYASICQQ
NGIVPIVEPE
ILPDGDHDLK
RCQYVTEKVL
AA
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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