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+1-617.299.7367 (Int’l)
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sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
| Introduction | The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis.Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. Beta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis. |
| Synonyms | Beta-defensin 1, BD-1, rBD-1, Defensin beta 1, Defb1. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | BD-1 protein was lyophilized from a 0.2 |
| Solubility | It is recommended to reconstitute the lyophilized BD-1 in sterile 18M-cm H2O not less than 100 |
| Stability | Lyophilized BD-1 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Amino Acid Sequence | DQYRCLQNGG FCLRSSCPSH TKLQGTCKPD KPNCCRS. |
| Purity | Greater than 95.0% as determined by:(a) Analysis by HPLC.(b) Analysis by SDS-PAGE. |
| Biological Activity | Measured by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 µg/ml. |
| Usage | NeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
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