BID Human-BID

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BID Human

Qty


Total
$65
Catalog #
PRPS-634
Size
Description
BID Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids and having a molecular mass of 21.9 kDa.
Additional Information
IntroductionBID accession number NP_001187 is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.
SynonymsBH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe protein solution contains 20mM Tris-HCl pH-8 & 20% NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMDCEVNNGSS
LRDECITNLL
VFGFLQSCSD
NSFRRELDAL
GHELPVLAPQ
WEGYDELQTD
GNRSSHSRLG
RIEADSESQE
DIIRNIARHL
AQVGDSMDRS
IPPGLVNGLA
LQLRNTSRSE
EDRNRDLATA
LEQLLQAYPR
DMEKEKTMLV
LALLLAKKVA
SHTPSLLRDV
FHTTVNFINQ
NLRTYVRSLA
RNGMD.
PurityGreater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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