BPGM Human-Mutase

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BPGM Human

Qty


Total
$65
Catalog #
ENPS-512
Size
Description
BPGM Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing267 amino acids (1-259 a.a.) and having a molecular mass of 31 kDa. The BPGM is fused to an 8 amino acid His Tag at C-Terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionBPGM is found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. PGM deficiency increases the oxygen affinity of cells. BPGM is a multifunctional enzyme that catalyzes 2,3-DPG synthesis throµgh its synthetase activity, and 2,3-DPG degradation using its phosphatase activity. BPGM has phosphoglycerate phosphomutase activity. Mutations in BPGM cause hemolytic anemia. BPGM catalyzes the reaction of EC 5.4.2.1 (mutase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
SynonymsBisphosphoglycerate mutase, EC 5.4.2.4, BPGM, 2,3-bisphosphoglycerate mutase erythrocyte, 2,3-bisphosphoglycerate synthase, BPG-dependent PGAM.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered clear colorless solution.
FormulationThe BPGM solution contains 20mM Tris-HCl pH-8, 1mM DTT, and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMSKYKLIMLR
HGEGAWNKEN
RFCSWVDQKL
NSEGMEEARN
CGKQLKALNF
EFDLVFTSVL
NRSIHTAWLI
LEELGQEWVP
VESSWRLNERHYGALIGLNR
EQMALNHGEE
QVRLWRRSYN
VTPPPIEESH
PYYQEIYNDR
RYKVCDVPLD
QLPRSESLKD
VLERLLPYWN
ERIAPEVLRG
KTILISAHGN
SSRALLKHLE
GISDEDIINI
TLPTGVPILL
ELDENLRAVG
PHQ
PurityGreater than 95% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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