CDC37 Human-Cell Division Cycle

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CDC37 Human

Qty


Total
$65
Catalog #
PRPS-471
Size
Description
CDC37 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 378 amino acids and having a molecular mass of 44.4 kDa.
Additional Information
IntroductionCDC37 is an essential protein in Saccharomyces cerevisiae and is a molecular chaperone with precise function in cell signal transduction. CDC37 forms a complex/associates with Hsp90 molecular chaperone as one of several auxiliary proteins that are collectively referred to as Hsp90 co-chaperones. CDC37 also forms complex with a number of protein kinases such as CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. CDC34 is involved in directing Hsp90 to its target kinases. CDC37 up-regulation is a common early event in some localized human cancers. CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multitargeted therapies. CDC37 plays a role in regulating Hsp90 ATPase activity. CDC37 binds to Akt and HSP90 in the signal transduction pathway in human tumor cells. Tnf-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. CDC37 and heat shock protein 90 bind specifically to the kinase domain of LKB1.
SynonymsP50CDC37, CDC-37, CDC37, Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, CDC37A, Cell Division Cycle 37.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe CDC37 protein solution contains 20mM Tris-HCl pH-8 & 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMVDYSVWDHI
EVSDDEDETH
PNIDTASLFR
WRHQARVERM
EQFQKEKEEL
DRGCRECKRK
VAECQRKLKE
LEVAEGGKAE
LERLQAEAQQ
LRKEERSWEQ
KLEEMRKKEK
SMPWNVDTLS
KDGFSKSMVN
TKPEKTEEDS
EEVREQKHKT
FVEKYEKQIK
HFGMLRRWDD
SQKYLSDNVH
LVCEETANYL
VIWCIDLEVE
EKCALMEQVA
HQTIVMQFIL
ELAKSLKVDP
RA
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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