CHGA Human, His-Chromogranin

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CHGA Human, His

Qty


Total
$65
Catalog #
PRPS-706
Size
Description
Recombinant Human CHGA produced in E.Coli is a single, non-glycosylated polypeptide chain containing 460 amino acids (19-457 a.a) and having a molecular mass of 51.2kDa (Molecular weight on SDS-PAGE will appear higher). Chromgranin-A is fused to 21 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionChromgranin-A is part of the neuroendocrine secretory protein family. CHGA is located in secretory vesicles of neurons and endocrine cells. Chromgranin-A is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. Chromgranin-A has numerous biological activities on some tissues and organs and exerts a large spectrum of homeostatic actions, including antifungal and antimicrobial effect, modulation of cell adhesion, and inhibition of parathyroid hormone secretion.
SynonymsCGA, CHGA, Vasostatin-2, Pituitary secretory protein I, SP-I.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe CHGA protein contains 20mM MES buffer pH-6, 2mM EDTA, 0.1mM PMSF and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MLPVNSPMNK
GDTEVMKCIV
EVISDTLSKP
SPMPVSQECF
ETLRGDERIL
SILRHQNLLK
ELQDLALQGA
KERAHQQKKH
SGFEDELSEV
LENQSSQAEL
KEAVEEPSSK
DVMEKREDSK
EAEKSGEATD
GARPQALPEP
MQESKAEGNN
QAPGEEEEEE
EEATNTHPPA
SLPSQKYPGP
QAEGDSEGLS
QGLVDREKGL
SAEPGWQAKR
EE
PurityGreater than 80.0% as determined by Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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