CMBL Human-Other

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CMBL Human

Qty


Total
$65
Catalog #
ENPS-641
Size
Description
CMBL Human Recombinant produced in E. coli is a single polypeptide chain containing 269 amino acids (1-245) and having a molecular mass of 30.6kDa.CMBL is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionCarboxymethylenebutenolidase homolog (CMBL) is a cysteine hydrolase of the dienelactone hydrolase family which is highly expressed in the liver cytosol. CMBL is the human homolog of Pseudomonas dienelactone hydrolase, which is a protein that participates in the bacterial halocatechol degradation pathway. CMBL which preferentially cleaves cyclic esters activates medoxomil-ester prodrµgs in which the medoxomil moiety is coupled with an oxygen atom. CMBL is inhibited by PCMB (p-chloromercuribenzoate) and is encoded by a gene which maps to human chromosome 5p15.2. Furthermore, CMBL converts the prodrµg olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, which is an angiotensin receptor blocker, in the liver and intestine. CMBL can also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. CMBL is widely expressed, with the highest levels in the liver, followed by the kidney, small intestine and the colon.
SynonymsCarboxymethylenebutenolidase homolog, CMBL, JS-1.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe CMBL solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM EDTA.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMANEAY
PCPCDIGHRL
EYGGLGREVQ
VEHIKAYVTK
SPVDAGKAVI
VIQDIFGWQL
PNTRYIADMI
SGNGYTTIVP
DFFVGQEPWD
PSGDWSIFPE
WLKTRNAQKI
DREISAILKY
LKQQCHAQKI
GIVGFCWGGT
AVHHLMMKYS
EFRAGVSVYG
IVKDSEDIYN
LKNPTLFIFA
ENDVVIPLKD
VSLLTQKLKE
HCKVEYQIKT
FS
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished forLABORATORY RESEARCHUSEONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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