DNAJB8 Human-Heat Shock Protein

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DNAJB8 Human

Qty


Total
$65
Catalog #
HYPS-057
Size
Description
DNAJB8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-232 a.a.) and having a molecular mass of 27.8kDa.DNAJB8 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionDnaJ homolog subfamily B member 8 (DNAJB8) is superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins.DNAJB8 is a member of the DNAJ/HSP40 family of proteins that regulate chaperone activity. DNAJB8 is (de)acetylated at 2 conserved C-terminal lysines which aren’t involved in substrate binding, but do have a role in suppressing protein aggregation. DNAJB8 has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma.
SynonymsDnaJ homolog subfamily B member 8, DNAJB8, DJ6.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe DNAJB8 solution (0.25mg/ml) 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15M NaCl and 1mM DTT.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MANYYEVLGV
QASASPEDIK
KAYRKLALRW
HPDKNPDNKE
EAEKKFKLVS
EAYEVLSDSK
KRSLYDRAGC
DSWRAGGGAS
TPYHSPFDTG
YTFRNPEDIF
REFFGGLDPF
SFEFWDSPFN
SDRGGRGHGL
RGAFSAGFGE
FPAFMEAFSS
FNMLGCSGGS
HTTFSSTSFG
GSSSGSSGFK
SVMSSTEMIN
GHKVTTKRIV
ENGQERVEVE
ED
PurityGreater than 90% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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