GCA Human-Other

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GCA Human

Qty


Total
$65
Catalog #
PRPS-087
Size
Description
GCA produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-217.a.) and having a molecular mass of 26.1kDa. GCA is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionGrancalcin is calcium-binding protein which is particularly abundant in human neutrophils. GCA is a member of the penta EF-hand (PEF) subfamily of EF-hand proteins, who also comprises calpain, sorcin, peflin, and ALG-2. GCA undergoes essential conformational changes upon binding of calcium, which subsequently exposes hydrophobic amino acid residues, that direct the protein to hydrophobic surfaces. GCA cooperates with L-plastin, a protein known to have actin bundling activity, which sµggests that GCA has a part in the regulation of neutrophils adhesion.
SynonymsGrancalcin EF-hand calcium binding protein, GCL, Grancalcin penta-EF-hand protein.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered clear solution.
FormulationThe GCA protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl and 20% glycerol.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAYPGYGGGF
GNFSIQVPGM
QMGQPVPETG
PAILLDGYSG
PAYSDTYSSA
GDSVYTYFSA
VAGQDGEVDA
EELQRCLTQS
GINGTYSPFS
LETCRIMIAM
LDRDHTGKMG
FNAFKELWAA
LNAWKENFMT
VDQDGSGTVE
HHELRQAIGL
MGYRLSPQTL
TTIVKRYSKN
GRIFFDDYVA
CCVKLRALTD
FFRKRDHLQQ
GSANFIYDDF
LQ
PurityGreater than 95% as determined by SDS-PAGE.
UsageNeoScientifics products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
StorageStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Background

N/A

Protocol

N/A

MSDS
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