GCK Human-Hexokinase

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GCK Human

Qty


Total
$65
Catalog #
PKPS-243
Size
Description
Glucokinase Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain fused to His tag at the N-terminal encoding the sequence of 485 amino acids and having a molecular mass of 54.3 kDa.HK4 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionHexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of Glucokinase results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, HK4 is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
SynonymsGlucokinase, EC 2.7.1.2, Hexokinase-4, Hexokinase type IV, HK IV, HK4, Hexokinase-D, GCK, GK, GLK, HHF3, HKIV, HXKP, MODY2.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe protein (1mg/ml) contains 20mM Tris-HCl pH-8.0 and 10% glycerol.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MLDDRARMEA
AKKEKVEQIL
AEFQLQEEDL
KKVMRRMQKE
MDRGLRLETH
EEASVKMLPT
YVRSTPEGSE
VGDFLSLDLG
GTNFRVMLVK
VGEGEEGQWS
VKTKHQMYSI
PEDAMTGTAE
MLFDYISECI
SDFLDKHQMK
HKKLPLGFTF
SFPVRHEDID
KGILLNWTKG
FKASGAEGNN
VVGLLRDAIK
RRGDFEMDVV
AMVNDTVATM
IS
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
StorageStore at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Background

N/A

Protocol

N/A

MSDS
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