GOPC Human-Other

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GOPC Human

Qty


Total
$65
Catalog #
PRPS-800
Size
Description
GOPC Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (278-454 a.a.) and having a molecular mass of 21.5 kDa. The GOPC is fused to a 20 amino acid His Tag and purified by conventional chromatography.
Additional Information
IntroductionGOPC is a PDZ domain-containing Golgi protein which binds the extreme C terminus of proteins in a sequence-specific manner. GOPC participates in intracellular protein trafficking and degradation. GOPC regulates CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. GOPC regulates the intracellular trafficking of the ADR1B receptor. GOPC takes part in autophagy. GOPC over expression results in CFTR intracellular retention and degradation in the lysosomes.
SynonymsCAL, dJ94G16.2, FIG, GOPC1, PIST, Golgi-associated PDZ and coiled-coil motif-containing protein, PDZ protein interacting specifically with TC10, CFTR-associated ligand, Fused in glioblastoma, GOPC.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe GOPC protein solution contains 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.
StabilityGOPC althoµgh stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MIRKVLLLKE
DHEGLGISIT
GGKEHGVPIL
ISEIHPGQPA
DRCGGLHVGD
AILAVNGVNL
RDTKHKEAVT
ILSQQRGEIE
FEVVYVAPEV
DSDDENVEYE
DESGHRYRLY
LDELEGGGNP
GASCKDTSGE
IKVLQGFNKK
AVTDTHENGD
LGTASETPLD
DGASKLDDLH
TLYHKKSY.
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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