GSR Human-Reductase

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GSR Human

Qty


Total
$65
Catalog #
ENPS-209
Size
Description
GSR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 504 amino acids (43-522) and having a molecular mass of 54.3kDa.GSR is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionGlutathione reductase (GSR) belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. The GSR enzyme is a homodimeric flavoprotein and has a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+ ->2GSH + NADP+. In the majority of eukaryotic cells, GSR upholds the ratio of [GSH] / [GSSG], and partakes in quite a few critical functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
SynonymsGlutathione reductase mitochondrial, GR, GRase, GSR, GLUR, GRD1.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe GSR solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSMAMACRQ
EPQPQGPPPA
AGAVASYDYL
VIGGGSGGLA
SARRAAELGA
RAAVVESHKL
GGTCVNVGCV
PKKVMWNTAV
HSEFMHDHAD
YGFPSCEGKF
NWRVIKEKRD
AYVSRLNAIY
QNNLTKSHIE
IIRGHAAFTS
DPKPTIEVSG
KKYTAPHILI
ATGGMPSTPH
ESQIPGASLG
ITSDGFFQLE
ELPGRSVIVG
AGYIAVEMAG
IL
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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