HB-EGF Mouse-Epidermal Growth Factor

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HB-EGF Mouse

Qty


Total
$65
Catalog #
CYPS-075
Size
Description
HB-EGF Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 86 amino acids (63-148 a.a.) and having a molecular mass of 9.8 kDa.The HB-EGF is purified by proprietary chromatographic techniques
Additional Information
IntroductionHB-EGF is an EGF related growth factor which signals via the EGF receptor, and stimulates the proliferation of SMC (smooth muscle cells), fibroblasts, epithelial cells and keratinocytes. HB-EGF is expressed in various cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes and particular tumor cells. HB-EGF’s ability to explicitly bind heparin and heparin sulfate proteoglycans is dissimilar from other EGF-like molecules, and might be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells.
SynonymsHeparin-binding EGF-like growth factor, DTR, HEGFL, diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor), DTSF, proheparin-binding epidermal growth factor-like growth factor.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationThe protein was lyophilized from a concentrated (1mg/ml) solution containing 1xPBS pH-7.4.
SolubilityIt is recommended to reconstitute the lyophilized Mouse HB-EGF in sterile 18M-cm H2O not less than 100
StabilityLyophilized Mouse HB-EGF Recombinant althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution HB-EGF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceDLEGTDLNLF
KVAFSSKPQG
LATPSKERNG
KKKKKGKGLG
KKRDPCLRKY
KDYCIHGECR
YLQEFRTPSC
KCLPGYHGHR
CHGLTL.
PurityGreater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Biological ActivityThe ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is < 1.0 ng/ml, corresponding to a specific activity of > 1.0
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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