HCV NS3 His-Hepatitis C

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HCV NS3 His

Qty


Total
$195
Catalog #
HCPS-274
Size
Description
The E.coli derived recombinant protein contains a total of 268 amino acids having a Mw of 27.9 kDa. The protein contains the HCV NS3 immunodominant regions, amino acids 1225-1456. The HCV NS3 protein is fused to a 36 His Tag at N-terminus and purified by standard chromatography techniques.
Additional Information
IntroductionHCV is a small 50nm, enveloped, single-stranded, positive sense RNA virus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host''s immune response. Hepatitis C virus is classified into six genotypes (1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
SynonymsNULL
SourceNULL
FormulationHCV NS3 in 20mM Tris-HCl pH-8, 1mM DTT & 10% Glycerol.
StabilityHCV-NS3 His althoµgh stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Amino Acid SequenceMRGSHHHHHH
GMASMTGGQQ
MGRDLYDDDD
KDRWGSVAHL
HAPTGSGKST
KVPAAYAAQG
YKVLVLNPSV
AATLGFGAYM
SKAHGVDPNI
RTGVRTITTG
SPITYSTYGK
FLADGGCSGG
AYDIIICDEC
HSTDATSILG
IGTVLDQAET
AGARLVVLAT
ATPPGSVTVS
HPNIEEVALS
TTGEIPFYGK
AIPLEVIKGG
RHLIFCHSKK
KCDELAAKLV
ALGINAVAYY
RG
PurityProtein is >95% pure as determined by SDS-PAGE.
UsageNeoScientific's products are furnished forLABORATORY RESEARCHUSEONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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