HSPB8 Human, His-Heat Shock Protein

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HSPB8 Human, His

Qty


Total
$65
Catalog #
HYPS-038
Size
Description
HSPB8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 216 amino acids (1-196 a.a.) and having a molecular mass of 23.7kDa. The HSPB8 is fused to a 20 amino acid His Tag at N-terminus and purified by conventional chromatography.
Additional Information
IntroductionHSPB8 is part of the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. HSPB8 is induced by estrogen in estrogen receptor-positive breast cancer cells. HSPB8 protein functions as a chaperone in association with BAG3, a stimulator of macroautophagy. HSPB8 participates in the regulation of cell proliferation, apoptosis, and carcinogenesis. Mutations in HSPB8 gene have been related with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
SynonymsHSPB8, H11, HMN2, CMT2L, DHMN2, E2IG1, HMN2A, HSP22, Heat shock protein beta-8, Alpha-crystallin C chain, Small stress protein-like protein HSP22, E2-induced gene 1 protein, Protein kinase H11, CRYAC.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe HSPB8 protein solution contains 20mM Tris-HCl pH-8, 100mM NaCl, and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MADGQMPFSC
HYPSRLRRDP
FRDSPLSSRL
LDDGFGMDPF
PDDLTASWPD
WALPRLSSAW
PGTLRSGMVP
RGPTATARFG
VPAEGRTPPP
FPGEPWKVCV
NVHSFKPEEL
MVKTKDGYVE
VSGKHEEKQQ
EGGIVSKNFT
KKIQLPAEVD
PVTVFASLSP
EGLLIIEAPQ
VPPYSTFGES
SFNNELPQDS
QEVTCT.
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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