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+1-888.733.6849
+1-617.299.7367 (Int’l)
Introduction | Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies). |
Synonyms | NULL |
Source | NULL |
Physical Appearance | Sterile Filtered clear solution. |
Formulation | (1mg/ml) 25mM Tris, 250mM Glycine and 0.1% SDS. |
Stability | Protein is shipped at ambient temperature. Upon arrival, Store at -20°C. |
Purity | Protein is >95% pure as determined by SDS-PAGE. |
Usage | NeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
Applications | Use as an antigen in ELISA and Western Blots. |
Purification Method | HTLV-I+II was purified by proprietary chromatographic technique. |
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