Interferon-beta 1a Human Recombinant produced in CHO (Chinese Hamster Ovarian) cells is a single, glycosylated polypeptide chain containing 166 amino acids and having a molecular mass of 22500 Dalton.IFN-beta1a is purified by proprietary chromatographic techniques.
Interferon-beta has antiviral, antibacterial and anticancer activities.
Leukocyte interferon, B cell interferon, Type I interferon, IFNB1, IFB, IFF, IFNB, IFN-b 1a ,MGC96956.
CHO (Chinese Hamster Ovarian) cells.
Lyophilized from a solution (1mg/3.4ml) containing 50mM Acetate acid pH 3.8.
It is recommended to reconstitute the lyophilized Interferon beta 1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Lyophilized Interferon-beta 1a althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFN-Beta1a should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Greater than 99.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 270 x 106 IU/mg.
NeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Title:Interferon-? induces apoptosis in human SH-SY5Y neuroblastoma cells throµgh activation of JAK–STAT signaling and down-regulation of PI3K/Akt pathway.Publication:Article first published online: 11 NOV 2010 DOI:10.1111/j.1471-4159.2010.07046.xLink:http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.07046.x/full