IGFBP 3 Human-IGFBP

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IGFBP 3 Human

Qty


Total
$65
Catalog #
CYPS-307
Size
Description
IGFBP3 Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated, polypeptide chain containing 2x264 amino acids and having a molecular mass of 28806 Dalton. IGFBP-3 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionIGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
SynonymsGrowth-hormone-dependant binding protein, IBP3, BP-53, IGFBP-3.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationLyophilized from a 0.2
SolubilityIt is recommended to reconstitute the lyophilized Insulin-Like Growth Factor Binding Protein-3 in sterile 20mM AcOH (acetic Acid) not less than 100
StabilityLyophilized IBP3 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGF-BP 3 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceGASSGGLGPV
VRCEPCDARA
LAQCAPPPAV
CAELVREPGC
GCCLTCALSE
GQPCGIYTER
CGSGLRCQPS
PDEARPLQAL
LDGRGLCVNA
SAVSRLRAYL
LPAPPAPGNA
SESEEDRSAG
EVESPSVSST
HRVSDPKFHP
LHSKIIIIKK
GHAKDSQRYK
VDYESQSTDT
QNFSSESKRE
TEYGPCRREM
EDTLNHLKFL
NVLSPRGVHI
PNCDKKGFYK
KKQCRPSKGR
KR
PurityGreater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Biological ActivityThe ED50, calculated by by its ability to inhibit IGF-II induced proliferation of MCF-7 is < 0.2
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
ReferencesTitle:The role of insulin-like growth factor binding protein-3 in the growth inhibitory actions of androgens in LNCaP human prostate cancer cells.Publication:Article first published online: 4 OCT 2007 DOI:10.1002/ijc.23100 Copyright
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